AMPK SIGNALING REGULATES MITOPHAGY AND MITOCHONDRIAL ATP PRODUCTION IN HUMAN TROPHOBLAST CELL LINE BEWO

Introduction: Accumulating evidence suggests that mitochondrial structural and functional defects are present in human placentas affected by pregnancy related disorders, but mitophagy pathways in human trophoblast cells/placental tissues have not been investigated.Methods: In this study, we investigated three major mitophagy pathways mediated by PR

Abstract Background To coordinate metabolite fluxes and energy availability, plants adjust metabolism and gene expression to environmental changes through employment of interacting signalling pathways.Results Comparing the response of Arabidopsis wild-type plants with that of the mutants adg1, pgr1 and vtc1 upon altered CO2-availability, the regula